Detailed view for PVX_114295

Basic information

TDR Targets ID: 269745
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 7.1605 | Length (AA): 660 | MW (Da): 72452 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00013   KH domain
PF16275   Splicing factor 1 helix-hairpin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0000398   nuclear mRNA splicing, via spliceosome  
GO:0045131   pre-mRNA branch point binding  
GO:0003676   nucleic acid binding  
GO:0008270   zinc ion binding  
GO:0003723   RNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
155 263 2bl5 (A) 1 118 37.00 0 1 0.47 -0.31
159 267 1k1g (A) 139 252 44.00 0 1 0.66 -0.06
11 165 2m0g (A) 6 145 37.00 0 1 0.503348 0.45
20 59 2emf (A) 1 40 5.00 0.00015 0 0.140406 -0.71
20 54 2emb (A) 2 35 9.00 0.75 0 0.19783 -1.16
51 153 4fxx (D) 28 131 40.00 0.00000029 1 0.597561 -0.98
148 267 4jvh (A) 73 202 38.00 0 1 0.651318 -0.76
159 267 1k1g (A) 139 252 44.00 0 1 0.703651 -0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intraerythrocytic - 6 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_128401)

Species Accession Gene Product
Arabidopsis thaliana AT5G51300   splicing factor 1-like protein
Babesia bovis BBOV_IV011380   transcription or splicing factor-like protein, putative
Brugia malayi Bm1_34515   Temporarily assigned gene name protein 44
Candida albicans CaO19.329   component of the splicing commitment complex
Candida albicans CaO19.7961   component of the splicing commitment complex
Caenorhabditis elegans CELE_Y116A8C.32   Protein SFA-1
Cryptosporidium hominis Chro.40142   transcription or splicing factor-like protein
Cryptosporidium parvum cgd4_1210   Ms15p; KH + 2 Znknuckle (C2HC)
Dictyostelium discoideum DDB_G0293554   CCHC-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG5836   Splicing factor 1
Echinococcus granulosus EgrG_000665700   zinc finger protein
Entamoeba histolytica EHI_193510   RNA-binding protein, putative
Echinococcus multilocularis EmuJ_000665700   zinc finger protein
Homo sapiens ENSG00000168066   splicing factor 1
Loa Loa (eye worm) LOAG_00808   hypothetical protein
Loa Loa (eye worm) LOAG_01156   hypothetical protein
Mus musculus ENSMUSG00000024949   splicing factor 1
Neospora caninum NCLIV_057750   hypothetical protein
Oryza sativa 9268114   Os04g0385700
Onchocerca volvulus OVOC7405  
Plasmodium berghei PBANKA_1122500   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0623600   transcription or splicing factor-like protein, putative
Plasmodium knowlesi PKNH_1126600   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_114295   hypothetical protein, conserved
Plasmodium yoelii PY04200   putative transcription or splicing factor
Saccharomyces cerevisiae YLR116W   Msl5p
Schistosoma japonicum Sjp_0001760   Splicing factor 1, putative
Schistosoma mansoni Smp_021540   zinc finger protein
Schmidtea mediterranea mk4.002237.00   Splicing factor 1
Schmidtea mediterranea mk4.018332.00  
Schmidtea mediterranea mk4.010871.01   Splicing factor 1
Schmidtea mediterranea mk4.003895.00   Splicing factor 1
Toxoplasma gondii TGME49_314860   zinc knuckle domain-containing protein
Theileria parva TP01_1166   transcription factor, putative
Trichomonas vaginalis TVAG_299630   conserved hypothetical protein
Trichomonas vaginalis TVAG_343950   zinc finger protein splicing factor, putative
Trichomonas vaginalis TVAG_293000   conserved hypothetical protein

Essentiality

PVX_114295 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y116A8C.32 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y116A8C.32 Caenorhabditis elegans larval arrest wormbase
CELE_Y116A8C.32 Caenorhabditis elegans slow growth wormbase
CELE_Y116A8C.32 Caenorhabditis elegans sterile wormbase
YLR116W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1122500 Plasmodium berghei Essential plasmo
TGME49_314860 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PVX_114295 (Plasmodium vivax), hypothetical protein, conserved
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